Trehalose enthalpy relaxation

As shown in Table 12.3, dry trehalose vitrifies at a higher temperature than do other disaccharides and the resultant glassy matrix is highly stable in the sense that enthalpy relaxation occurs with more difficulty than in other... 

Structural relaxation times determined from enthalpy relaxation studies with sucrose and trehalose [37,50] are given in Figure 8. The structural relaxation times observed are qualitatively similar to those estimated for the fragile glass... 

Figure 8 Structural relaxation times for quench-cooled glassy disaccharides as determined from enthalpy relaxation data. Structural relaxation times were obtained by a fit of the data to the stretched exponential function (see [37,50]). ( ) Data for sucrose obtained by differential scanning calorimetry on annealed samples [37], (O) Data for sucrose obtained by isothermal microcalorimetry [50]. (A) Data for trehalose obtained by isothermal microcalorimetry [50].

Kawai, K., Hagiwara, T., Takai, R., and Suzuki, T. Comparative investigation by two analytical approaches of enthalpy relaxation for glassy glucose, sucrose, maltose and trehalose, Pharm. Res., 2004, in press. 

Pyne, A., Surana, R., and Suryanarayanan, R. Enthalpis relaxation in frozen aqueous trehalose solutions, Thermochim. Acta, 405, 225, 2003. 

Structural relaxation times determined from enthalpy relaxation studies with sucrose and trehalose [39,53] are given in Figure 8. The structural relaxation times observed are qualitatively similar to those estimated for the fragile glass example in Figure 7. While there is considerable scatter in the data, it seems clear that the temperature dependence for sucrose is nonlinear and therefore non-Arrhenius. Insufficient data are available for trehalose to judge linearity. The trehalose structural... 

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