Trecator - Ethionamide

Trecator (Ethionamide). Wyetii Pharmaceuticals Inc. US Prescribing inform ation, Septem ber 2006. [Pg.50]

Ethionamide (Trecator) is a derivative of isonicotinic acid and is chemically related to isoniazid. It is a secondary agent used in combination when primary agents are ineffective or contraindicated it is a bacteriostatic antituberculosis agent. Its exact mechanism of action is unknown but is believed to involve inhibition of oxygen-dependent mycolic acid synthesis. It is thought that mutations in the region of the (tnhA) gene that are involved in mycolic acid synthesis can cause both isoniazid and ethionamide resistance. [Pg.561]

Kanamycin (Kantrex) Erythromycin ethylsuccinate (E.E.S., EryPed, others) Minocycline (Minocin) Ethionamide (Trecator-SC)... [Pg.507]

Council on Drugs. Ethionamide. A tuberculostatic agent (Trecator). JAMA 1964 187(7) 527. [Pg.1296]

Desmons MT. Aspect pseudolupique provoque par I ethionamide (Trecator). Bull Soc Franc Derm Syph 1973 80 168. [Pg.1296]

Ethionamide (2-ethylthioisonicotinamide, Trecator SC, 8) is an antibiotic prodrug used in the treatment of tuberculosis. One synthetic pathway involves the condensation of diketo-ester 160 with cyanoacetamide 161 followed by hydrolysis of the resulting pyridone 162 into give pyridone acid 163. Treatment of 163 with POCI3 converts the lactam to imine chloride and simultaneous ester formation in ethanol to give 164. Hydrogenation of 164 to remove the chloride, amide formation, and sequential conversion to the thioamide provided 8." ... [Pg.430]

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