Trazodone Protease inhibitors

A4 Barbiturates, carbamazepine, corticosteroids, efavirenz, phenytoin, rifampin, troglitazone Antiarrhythmics, antidepressants, azole antifungals, benzc iazepines, calcium channel blockers, cyclosporine, delavirdine, doxorubicin, efavirenz, erythromycin, estrogens, HIV protease inhibitors, nefazodone, paclitaxel, proton pump inhibitors, HMG-CoA reductase inhibitors, rifabutin, rifampin, sildenafil, SSRIs, tamoxifen, trazodone, vinca anticancer agents... 

Zalma A, von Moltke LL, Granda BW, Harmatz JS, Shader RI, Greenblatt DJ. In vitro metabolism of trazodone by CYP3A inhibition by ketoconazole and human immunodeficiency viral protease inhibitors. Biol Psychiatry 2000 47 655-661. 

Ritonavir impairs the clearance of trazodone with an increased potential for adverse effects. Other protease inhibitors may interact similarly. 

The FDA in the US and the manufacturers of trazodone recommend that a lower dose of trazodone should be considered if it is given with potent CYP3A4 inhibitors sueh as the protease inhibitors ritonavir and indina-vir. However, the UK manufaeturer also suggests that the eombination should be avoided where possible. ... 

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