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Trapping studies drug toxicity

Reactive Metabolite Trapping and Covalent Binding Studies as Predictors of Idiosyncratic Drug Toxicity... [Pg.43]

REACTIVE METABOLITE TRAPPING AND COVALENT BINDING STUDIES AS PREDICTORS OF IDIOSYNCRATIC DRUG TOXICITY... [Pg.68]

With the exception of trovafloxacin, none of the other drugs in the fluoroquinolone class of antibiotics have been associated with idiosyncratic hepatotoxicity. From a structure-toxicity standpoint, it is interesting to note the presence of the cyclopropylamine structural alert at the C7 position of the fluoroquinolone scaffold in trovafloxacin. Studies with a model compound have revealed cyclopropylamine ring bioactivation by CYP and myeloperoxidase to a reactive a,P-unsaturated aldehyde trapped as a sulfydryl conjugate... [Pg.64]

See other pages where Trapping studies drug toxicity is mentioned: [Pg.35]    [Pg.143]    [Pg.348]    [Pg.348]    [Pg.351]    [Pg.356]    [Pg.216]    [Pg.281]    [Pg.282]    [Pg.122]    [Pg.156]    [Pg.105]    [Pg.106]    [Pg.118]    [Pg.292]    [Pg.183]    [Pg.221]    [Pg.310]    [Pg.2070]    [Pg.46]    [Pg.73]    [Pg.499]    [Pg.784]    [Pg.159]    [Pg.3624]    [Pg.116]    [Pg.106]    [Pg.1308]   
See also in sourсe #XX -- [ Pg.68 , Pg.69 , Pg.70 ]



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