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Transscleral Drug Delivery to the Retina and Choroid

Department of Ophthalmology and Visual Sciences and Physiology, University of Kentucky, Lexington, Kentucky, U.S.A. [Pg.193]

Subconjunctival injections of sustained-release matrix materials or microparticles have produced significant levels in the vitreous cavity. Although the kinetics of transscleral drug delivery to the retina and choroid are... [Pg.19]

The intrascleral implant is a device that is implanted in the sclera it delivers the drug through the sclera to the intraocular tissues (Fig. 5). Transscleral delivery may be an effective method of achieving therapeutic concentrations of drugs in the posterior segment (24-27). The intrascleral implant that incorporated betamethasone phosphate (BP) successfully delivered the drug to the retina/choroid and vitreous (28). The concentration of BP was maintained at a level that should suppress inflammation in the retina-choroid for more than eight weeks, and did not produce any ocular toxicity. [Pg.178]

See other pages where Transscleral Drug Delivery to the Retina and Choroid is mentioned: [Pg.193]    [Pg.195]    [Pg.197]    [Pg.199]    [Pg.201]    [Pg.193]    [Pg.195]    [Pg.197]    [Pg.199]    [Pg.201]    [Pg.198]    [Pg.199]    [Pg.179]    [Pg.189]    [Pg.197]   


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Choroid

Retina

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