Transport vesicles, protein sorting

Cosson P and Letourneur F (1997). Coatomer (COP1 )-coated vesicles role in intracellular transport and protein sorting. Curr Opin Cell Biol, 9, 484-487. 

Along their route through the Golgi, secretory and membrane proteins destined for the various post-Golgi pathways are intermixed. Thus, proteins of distinct routes, i.e. the endosomal and the secretory route, are sorted into individual types of transport vesicles at the TGN. Among the best characterized types of TGN-derived vesicles are clathrin-coated vesicles. In addition, several types of non-clathrin-coated vesicles have been identified but their specific functions remain to be characterized. 

Rothman JE, Wieland FT (1996) Protein sorting by transport vesicles. Science 272 227-234... 

Membrane proteins inside transport vesicles bud off the endoplasmic reticulum on their way to the Golgi final sorting of many membrane proteins occurs in the trans-Golgi network. 

Le Borgne, R., and Hoflack, B. (1998a). Mechanisms of protein sorting and coat assembly insights from the clathrin-coated vesicle pathway. Curr. Opin. Cell Biol. 10, 499-503. Le Borgne, R., and Hoflack, B. (1998b). Protein transport from the secretory to the endocytic pathway in mammalian cells. Biochim. Biophys. Acta 1404, 195-209. 

FIGURE 27-35 Pathway taken by proteins destined for lysosomes, the plasma membrane, or secretion. Proteins are moved from the ER to the cis side of the Golgi complex in transport vesicles. Sorting occurs primarily in the trains side of the Golgi complex. 

Transport Vesicles Carry Proteins from the Endoplasmic Reticulum to the Golgi Complex for Further Glycosylation and Sorting... 

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