Transport, Uptake, and Control

The pathway for uptake involves several steps, including the following  

The assembly of the receptor-LDL complexes into a coated pit on the cell surface. 

The pit folds into a spherical endosome, which is a small vesicle of cell membrane with receptor-LDL complexes on the inside. 

The endosome fuses with a lysosome containing a large number of degradative enzymes and a low pH on the inside. 

The receptors separate from the endosome-lysosome and return to the cell surface. 

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