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Transition-metal catalysts, ring-closure reactions

The asymmetric synthesis of cyclopropanes has attracted continual efforts in organic synthesis, due to their relevance in natural products and biologically active compounds. The prevalent methods employed include halomethylmetal mediated processes in the presence of chiral auxiliaries/catalysts (Simmons-Smith-type reactions), transition-metal-catalyzed decomposition of diazoalkanes, Michael-induced ring closures, or asymmetric metalations [8-10,46], However, the asymmetric preparation of unfunctionahzed cyclopropanes remains relatively undisclosed. The enantioselective activation of unactivated C-H bonds via transition-metal catalysis is an area of active research in organic chemistry [47-49]. Recently, a few groups investigated the enantioselective synthesis of cyclopropanes by direct functionalization reactions. [Pg.106]

The rapid development of organocatalysis impels chemists to discover new synthetic methodologies. Many important transformations that could only be realized by transition metal catalysis can now be achieved via organocatalysis. In 2010, Kim and coworkers reported a novel C-H bond functionalization reaction via a tandem 1,5-hydride transfer/ring closure sequence. Based on the iminium-enamine cascade activation of catalyst 33, the fused tetrahydroquino-Unes 35 could be synthesized from substrates 34 with good stereoselectivity. This is the first example of an organocatalytic intramolecular redox reaction (Scheme 36.10) [16]. [Pg.1074]


See other pages where Transition-metal catalysts, ring-closure reactions is mentioned: [Pg.168]    [Pg.1]    [Pg.167]    [Pg.185]    [Pg.24]    [Pg.1146]    [Pg.1151]    [Pg.225]    [Pg.169]    [Pg.95]    [Pg.479]    [Pg.177]    [Pg.116]    [Pg.110]    [Pg.11]    [Pg.110]    [Pg.110]    [Pg.475]    [Pg.458]    [Pg.548]    [Pg.548]   
See also in sourсe #XX -- [ Pg.169 , Pg.170 , Pg.171 , Pg.172 , Pg.173 ]




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Metal rings

Ring closure reactions

Ring closures catalysts

Transition catalyst

Transition metal catalysts reactions

Transition metal reactions

Transition metal rings

Transition-metal catalysts, ring-closure

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