Transition metal catalysed reactions of zinc organometallics

PAUL KNOCHEL, PHILIP JONES, and FALK LANGER 

Michael-addition reactions can be performed with various zinc/copper reagents derived from organozinc halides. (3-Monosubstituted enones react in 

Addition reaction of zinc-copper reagents to nitro olefins is a versatile method for preparing polyfunctional nitroalkanes.20 A direct ozonolysis of the intermediate zinc nitronate furnishes the corresponding ketone (Nef-reaction).20 

The treatment of diorganozincs or organozinc halides with cobalt bromide in THF NMP mixtures provides blue solutions of organocobalt reagents, which have a half-life of several hours at -20 °C.25,26 Carbonylation reactions with these new cobalt reagents proceed well simply by bubbling carbon monoxide 

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Transition metal catalysed reactions of zinc organometallics... 

The most important developments in heterocyclic chemistry in the last twenty or so years are probably in the area of organometallic chemistry, particularly transition-metal-catalysed reactions and the reactions of lithio-derivatives, reflecting development in these areas in organic chemistry as a whole. Even since the 3rd Edition of this book, significant further advances have been made, with improved preparations of boron, magnesium, and zinc compounds and with new ligands for palladium-catalysed reactions which considerably broaden their scope. 

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