Transition element complexes thermodynamic effects

The impact of nucleophilic and electrophilic groups of the active center on the substrate at the contact area in the enzyme-substrate complex (the effect of synchronous intramolecular catalysis). The polyfunctional catalysis involves a great many processes push-pull mechanisms, processes involving a relay charge transfer, as well as a general acid-base catalysis. Presumably, the enzyme in the initial state of the enzymatic reaction already contains structural elements of the transition state and in this case the reaction must be thermodynamically more advantageous. 

Geoffroy, George, L., Photochemistry of Transition Metal Hydride Complexes George, J. W., Halides and Oxyhalides of the Elements of Groups Vb and VIb George, Philip and McClure, Donald S., The Effect of Inner Orbital Splitting on the Thermodynamic Properties of Transition Metal Compounds, and... 

Although relatively understudied compared to transition metals, Pb(II) exhibits a rich coordination chemistry. Because lead is subject to relativistic effects, the electronic properties of Pb(ll) complexes are diverse and interesting. Fortunately, a wide variety of spectroscopic techniques are available to probe the properties of these compounds. In addition, detailed studies on the structures, kinetics, and thermodynamics of lead compounds provide important insights into the environmental and biological chemistry of lead(II). Through this chapter, we hope not only to have provided an overview to the chemistry of Pb(ll), but also to have corrected several misconceptions about this element ... 

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