Transgenics null mice

Figure 17.2.3. The response to PPs is lost in a transgenic mouse that has had its DNA altered so that it no longer has the regulatory protein, PPARa. In the PPARa null mouse, there is no peroxisome proliferation, cell proliferation, liver enlargement nor tumors in response to PPs.

In the recent years, an increasing number of studies show widespread relevance of the CaMK cascade. From the recent description of new isoforms, such as those of the CaMKI subfamily, to the analysis of mouse models null or transgenic... 

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