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Transfection efficiency molecular weight

Fischer, D., Bieber, T., Li, Y., Elsasser, H-P, Kissel, T. (1999). A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine effect of molecular weight on transfection efficiency and cytotoxicity. Pharm. Res., 16, 1273-12791. [Pg.369]

Werth S, Urban-Klein B, Dai L, Hdbel S, Grzelinski M, Bakowsky U, Czubayko F, Aigner A (2006) A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes. J Control Release 112(2) 257-270... [Pg.14]

Furthermore, we studied the influence of the molecular weight and degree of branching on transfection efficiency and cell toxicity, which is supposed to have influence, as initially analyzed in several adherent cell lines (NIH/3T3, CHO-K1, COS-7, and HeLa), with unfunctionalized poly(ethylene imine)s [91, 95, 96]... [Pg.103]

Fig. 6). The highest efficiencies were observed for polymers whose PEI cores had molecular weights between 15 and 60 kDa. Along with increasing core size the cytotoxicity also increased. The DNA transfection efficiency, however, depended on the investigated cell line. [Pg.104]

Duceppe N, Tabrizian M (2009) Factors influencing the transfection efficiency of ultra low molecular weight chitosan/hyaluronic acid nanoparticles. Biomaterials 30(13) 2625-2631... [Pg.185]

Huang M, Fong C-W, Khor E et al (2005) Transfection efficiency of chitosan vectors effect of polymer molecular weight and degree of deacetylation. J Control Release 106(3) 391—406... [Pg.186]

Chemical programming of polymers has proven to be a crucial tool in mimicking virus-like features. Thus, alterations in polymer structure and conformation can be correlated to transfection efficiency and cytotoxicity. It has to be considered that the better polymer structure is defined, the more detailed study of structure-activity relationships is possible. First approaches towards better defined polymer structure with narrow molecular weight distribution have been made by PAE and pseudo-dendrimer synthesis already discussed in Sect. 4.1. [Pg.239]

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See also in sourсe #XX -- [ Pg.379 ]



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