Transdermal and transmucosal systems

Due to its higher plasticity (see Fig. 110), its lower hygroscopicity (see Fig. 96) and its bioadhesion the film former copovidone can be more suitable than povidone for transdermal or transmucosal systems. There is also described a crystallization inhibitory effect of in transdermal/transmucosal systems of dihydroergotamine, melatonine, betamethasone and fusafungine [58,590]. The bioadhesion of copovi- 

A typical basic formulation of a mucoadhesive buccal tablet is given in Table 182. In this case the adhesive effect of copovidone was much higher than the adhesion of povidone K 30 or povidone K 90. 

Mix intensively the components I, granulate mixture I with ethanol II, pass through a 0.8 mm sieve, dry, sieve again through a 0.5 mm sieve, mix with the component 111 and press with medium compression force to tablets. 

One drop of human saliva was given to a glass plate and a tablet was put on this drop. After 7 min the force (N) needed to separate the tablet vertically from the glass plate was measured  

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