Transcutaneous Electrical Resistance

Rat transcutaneous electrical resistance (TER) skin corrosivity test EU, US... [Pg.80]

To test the irritancy potential of substances, two tests which can reliably distinguish between skin corrosives and noncorrosives are endorsed by the European Centre for the Validation of Alternative Methods (ECVAM). The testing procedures are based on the transcutaneous electrical resistance (TER) measurements of rat skin and on a human skin model. Both test systems [141-145] will be briefly outlined below. Nevertheless, these tests are not suited for the group of mild irritants which do not induce an acute effect on the barrier function. For those substances, new markers need to be evaluated. First results are available for heat shock protein 27 where higher levels were observed in skin models after exposure to mildly irritating chemicals [146, 147]. [Pg.21]

OECD. Test guideline 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance, OECD, Paris, 2004. [Pg.32]

ECVAM. News and Views. Statement on the scientific validity of the rat skin transcutaneous electrical resistance (TER) test (an in vitro test for skin corrosivity). ATLA 26 275-280 (1998). [Pg.32]

ICCVAM has validated three tests for dermal corrosion, including Corrositex , EPISKIN / EpiDerm, and Transcutaneous Electrical Resistance (TER). [Pg.60]

Two in vitro tests for the assessment of skin corrosion, the Transcutaneous Electrical Resistance [TER] Assay (TG 430) and the human Skin Model Test (TG 431) (Section... [Pg.61]

In vitro skin corrosion Transcutaneous electrical resistance test (TER)... [Pg.113]

Toxicology and Environmental Health Information Program Transcutaneous Electrical Resistance Test Guideline... [Pg.449]

Organization for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals No. 430 in vitro Skin Corrosion — Transcutaneous Electrical Resistance Test (TER), Paris, France, 2002a. [Pg.413]

Transcutaneous electrical resistance assay - mouse skin disk Corrosion... [Pg.2726]

Furthennore, some materials, including medical textiles, have the potential to cause allergy or irritation. The sensitization potential of the material is therefore required to be tested. The ISO 10993-10 assesses the possible contact hazards from chemicals released from the devices, which may produce skin, mucosal, or eye irritation and skin sensitization. Currently, there has been no satisfactory in vitro test to eliminate the requirement for in vivo testing to evaluate irritation. However, the rat skin Transcutaneous Electrical Resistance (TER) test and the human skin model test have been internationally validated and accepted as alternative tests to assess the skin corrosion with chemicals (OECD, 2009a,b). To perform the test, an animal (rabbit) with the healthy intact skin needs to be used and the fur on the back of animal is clipped 24-4h of testing with approximate size of 10cmX 15 cm and then 0.5g or 0.5 mL of materials apply to the site and then the application site is covered with... [Pg.146]

In the past, skin corrosion was assessed using animal studies (OECD TG 404, 2002) but recently three in vitro tests for skin corrosivity are used. The rat skin transcutaneous electrical resistance (TER) assay and a test employing a human skin model are included in Annex V of the Dangerous Substances Directive (Directive 2000/33/EC, B.40. Skin corrosion) and also proposed as an OECD draft for testing guidelines TG 430 (OECD, 2004a) and TG 431 (OECD, 2004b) (Table 9.1.1). [Pg.427]

Figure 9.1.1 Device to determine the transcutaneous electrical resistance (TER) test through the rat skin disc (B.40. Skin corrosion, Directive 2000/33/EC).

NIH, 2002, ICCVAM Evaluation of EPISKIN , EpiDerm , EPI-200, and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay In Vitro Test Methods for Assessing Dermal Corrosivity Potential of Chemicals, NIH Publication No. 02-4502, NIEHS, Research Triangle Park, NC, USA. [Pg.454]

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