Transcription and Translation of Collagen Polypeptides

IV ADorAR Decreased type III collagen synthesis and its intracellular accumulation Heterogeneous 

VII AD Deletion of exons from the genes of proa,) ) and prott2(I) that encode the amino-terminal cleavage site required for the action of procollagen aminoprotease Heterogeneous 

Decreased synthesis of proa, (I), leading to less production of type I collagen because of several defects in the gene. 

Markedly diminished synthesis of type I collagen presence of hydroxylysine-enriched collagens associated with delayed helix formation. 

Delayed secretion of type I procollagen associated with excess mannose residues in the carboxyterminal propeptide region absence of synthesis. 

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