1.2- trans-Disaccharides

Hanessian, S, Banoub, J, Chemistry of the glycosidic linkage. An efficient synthesis of 1,2-trans-disaccharides, Carbohydr. Res., 53, C13-C16, 1977. 

Cloran, F., Carmichael, I., Serianni, A. S., 1999b, Density Functional Calculations on Disaccharide Mimics Studies of Molecular Geometries and Trans-O-glycosidic 3Jcoch and 3Jcocc Spin Couplings , J. Am. Chem. Soc., 121, 9843. 

Molecular mechanics calculations for disaccharides (7,18 Imberty, A. Tran, V. Perez S. J. Comp. Chem., in press also see below), not surprisingly, have shown that the assumption of rigid geometry leads to artificially steep potential energy surfaces. 

Widmalm et al.354 reported the measurement of 3J(C, H) couplings through glycosidic linkages in p-linked disaccharides and also for vicinally disubstituted trisaccharides. Widmalm with other co-authors355 reported the measurement of trans-glycosidic 3J(C,H) couplings in the trisaccharide 2 -fucosyllactose. 

---