Tracheal antimicrobial peptide

Yarus, S., Rosen, J.M., Cole, A.M., and Diamond, G. (1996). Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice. Proc. Natl. Acad. Sci. USA 93, 14118-14121. 

A subset of defensins, the P-defensins, have been isolated from bovine neutrophils (10). A unique consensus sequence distinguishes these defensins from those described above, although both contain the characteristic three disulfide bridges. Tracheal antimicrobial peptide (TAP) isolated from the bovine respiratory tract also contains the triple disulfide motif but is specifically expressed in the lespiratory tract (II). This peptide is active against Cram-negative and -positive bacteria and yeast,... 

Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL. Tracheal antimicrobial peptide, a cysceine-rich peptide from mammalian tracheal mucosa Peptide isolation and cloning of a cDNA. Proc Natl Acad Sci USA 1991 88 3952-3956. 

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