Tracer folate

Tracer Folates and SIDAs in Folate Analysis of Clinical Samples... 

Mathias, C. J., Waters, D. J., Wang, S Low, P. S and Green, M. A. (1997) Indium-111 labeled Indium(III)-DTPA-folate as a radiopharmaceutical for targeting tumor-associated folate receptors the effect of tumor size on targeting selectivity and radiochemical analysis of excreted tracer, in 12th International Symposium on Radiopharmaceutical Chemistry, Uppsala, Sweden. 

Many short-term kinetic studies have been reported on the basis of plasma and senun folate levels in humans. Typical protocols involve the administration of a folate tracer dose to folate-saturated subjects or else a large folate dose given to subjects of more normal folate status (Reich and Gonczy, 1979 Bunni et aL, 1989 Wolfrom et al, 1990 Priest et al, 1991 von der Porten et al, 1992). Although these studies have clinical relevance with respect to the short-term kinetics of acute doses of the vitamin (e.g., postchemotherapy 5-formyl-tetrahydrofolate), they often provide little or no information about the major body folate pool that exhibits much slower kinetics. 

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