Tpte protecting group

TPP = 5,10,15,20-tetraphenylporphine, 252 Tpte protecting group, 216, 217 Trajectories in reactions of nucleophiles, 316 trans-Selectivity. See cis/trans Transcriptase, reverse, 242 Transform, retro-synthetic, 193-196 Triamterene, 308 Trias teranone, 94... 

Tpte [2-[(4-tritylphenyl)thio]ethyl] Z = Cbz benzyloxycarbonyl protecting group... 

Protection of 5 -phosphate group in synthesis of dinucleotides. The 5 -phosphate group of mononucleotides is converted into 5 -esters by reaction with (I) in the presence of triisopropylbenzenesulfonyl chloride (TPS 1, 1228-1229 3, 308) or DCC. The esters are then condensed with a 3 -0-acetylated mononucleotide in pyridine with TPS to form TPTE-dinucleotides in 50 0% yield. The value of (1) is that it confers lipophilic properties on the protected dinucleotides so that they can be extracted into ethyl acetate-butanol or methylene chloride-butanol. The protecting group is removed by oxidation to the corresponding sulfone (NCS) and -elimination. 2-(p-Tritylphenyl)sulfonylethanol (TPSE) can be used in place of (1) in this event, the oxidation step is not necessary. A number of tri-and tetranucleotides were also prepared by this new method. ... 

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