Toxicity effects palladium chemistry

Unfortunately ds-platin derivatives induce various side effects such as neuro- and renal toxicities, and bone marrow suppression. Based on the chemistry of chromone derivatives, Budzisz extended their appHcation (see Section 2.6 Topoisomerase II inhibitors) to the formation of the palladium and platinum complexes 49 (Figure 9) as analogs of ds-platin (04PJP473). 

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