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Drugs toxicity

Stanley LA, Horsburgh BC, Ross J et al (2006) PXR and CAR nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. Drug Metab Rev 38 515-597... [Pg.893]

Fhtients with liver or kidney disease are usually given dragp with caution because a cumulative effect may occur. When the patient is unable to excrete the drug at a normal rate the drug accumulates in the body, causing atoxic reaction. Sometimes, the primary health care provider lowers the dose of the drug to prevent a toxic drug reaction. [Pg.10]

The nurse must carefully monitor fluid intake and output because this drug may be nephrotoxic (harmful to the kidneys). In some instances, the nurse may need to perform hourly measurements of the urinary output. Periodic laboratory tests are usually ordered to monitor the patient s response to therapy and detect toxic drug reactions. [Pg.135]

LEUCOVORIN. When leucovorin is administered after a large dose of methotrexate, the timing of tiie administration is outlined by tiie primary health care provider. It is essential that the leucovorin be given at tiie exact time ordered because tiie purpose of folinic acid rescue is to allow a high dose of a toxic drug to remain in tiie body for only a limited time... [Pg.440]

Baselt RC, Cravey RH The Disposition of Toxic Drugs and Chemicals in Man, 3rd Edition. London, Year Book Medical, 1989 Bordo DJ, Dorfman MA Ecstasy overdose rapid cooling leads to successful outcome. Am] Emerg Med 22 326-327, 2004... [Pg.237]

In comparison with the intravenous route of administration the potential advantages of intraperitoneal therapy are the avoidance of high toxic drug plasma levels and an increased (local) exposure of tumors (cells) to anticancer drugs. Whether this increased exposure... [Pg.300]

Lash LH, Xu Y, Elfarra AA, et al. 1995. Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity. Drug Metabolism and Disposition 23 846-853. [Pg.276]

Baselt, R.C., ed. Phencvclidine-disposition of Toxic Drugs and Chemicals in Man. Davis, California Biomedical Publications, 1982. 785 pp. [Pg.229]

Obtain a complete history of alcohol intake and hepato-toxic drug use, including over-the-counter products and dietary supplements. [Pg.335]

The hydrazine-aldehyde reaction has been used intracellularly to deliver non-toxic drug components, which when linked to form a hydrazone bond in situ, become cytotoxic (Rideout, 1986, 1994 Rideout et al., 1990). This same approach has been used to generate enzyme inhibitors in vivo, wherein the hydrazine and aldehyde precursors are not active, but when coupled together within cells to form a hydrazone linkage, become active site binders (Rotenberg etal, 1991). [Pg.671]

Baselt RC (2004) Disposition of toxic drugs and chemicals in man, 7th edn. Biomedical Publications, Foster City, p 1254... [Pg.207]

It is probably best to avoid p-methoxyamphetamine (PMA) and 2,5-dimethoxy-4-methylamphetamine (STP), the former because it seems to have a high toxicity and the latter because it lasts too long (e.g., 24 hours for a minimum dose). Other 4-alkyl amphetamines also seem to be toxic. A number of apparent fatalities due to MDA have been noted, but the reports usually involve very large amounts, often in combination with other drugs (e.g., 7 g MDA plus barbiturates) and screening for other, more toxic drugs (in particular, PMA) has not been done. [Pg.93]

Nelson SD, Trager WF. The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity. Drug Metab Dispos 2003 31(12) 1481—1498. [Pg.32]

More precise control of levels of drug than with other routes, especially of toxic drugs, where the levels must be kept within narrow limits. [Pg.450]

With the advent of computer-aided-drug modeling (CADM) the critical, scientific and faster approach to newer drug entities based on the biologically active prototypes, combinatorial chemistry, chiral chemistry and biotechnology has paved the way towards more specific, potent and above all less toxic drugs to improve the ultimate quality of life in humans. [Pg.537]

Acute Nicotine is a very toxic drug in acute high doses (Taylor 1996). The lethal dose in adult humans is approximately 60 mg. Symptoms of acute poisoning include headache, dizziness, salivation, cold sweats, abdominal pain, nausea, vomiting, and diarrhea. Sensory disturbances, confusion, and convulsions also occur. Blood pressure drops, the pulse becomes weak and irregular, and respiration becomes difficult. Death usually results from respiratory failure. [Pg.117]

Halpern JH, Pope HG Jr. (1999). Do hallucinogens cause residual neuropsychological toxicity Drug Alcohol Depend. 53(3) 247-56. [Pg.542]

McGrath P, Li CQ (2008) Zebrafish a predictive model for assessing drug-induced toxicity. Drug Discov Today 13 394-401... [Pg.410]

Note The above formula is obviously a rapid, convenient procedure, and eliminates the need to isolate intermediates and other time consuming operations. The procedure above is described for the p-methoxy derivative, a potent but toxic drug. If you wish to avoid the toxic quality of the p-methoxy derivative the formula may be used to make other phenethyl amines without substantive modification. [Pg.42]

So far, clinical evaluation [396-9] has given hope of a measure of control of Pseudomonas with, for the first time, a non-toxic drug. In view of previous calamities a recent reviewer [400] commented to make the best use of carbenicillin both the minimim inhibitory concentration for each strain of organism and the level of the antibiotic in serum must be established. Unfortunately, the next sentence reads. We fear that in most hospitals this will remain a council of perfection . It is to be hoped that this drug will not be squandered like so many of its predecessors. [Pg.52]


See other pages where Drugs toxicity is mentioned: [Pg.361]    [Pg.421]    [Pg.770]    [Pg.238]    [Pg.62]    [Pg.475]    [Pg.666]    [Pg.197]    [Pg.289]    [Pg.1450]    [Pg.693]    [Pg.754]    [Pg.82]    [Pg.529]    [Pg.443]    [Pg.253]    [Pg.148]    [Pg.395]    [Pg.327]    [Pg.625]    [Pg.18]    [Pg.77]    [Pg.671]    [Pg.340]    [Pg.517]    [Pg.346]    [Pg.130]    [Pg.357]    [Pg.494]    [Pg.3]   
See also in sourсe #XX -- [ Pg.882 ]

See also in sourсe #XX -- [ Pg.163 , Pg.399 ]




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Activity and Toxicity of Gold Drugs

Acute Toxicity Testing in Drug Safety Evaluation

Adverse drug reactions Toxicity

Adverse drug reactions systemic toxicity

Alpha-blocking drugs toxicity

Anti-inflammatory drugs toxicity

Antiarrhythmic drugs toxicity

Anticancer drugs selective toxicity

Anticancer drugs toxicity

Antiepileptic drug toxicity

Antimicrobial agents/drugs toxicity

Antimuscarinic drugs toxicity

Antiparasitic drugs selective toxicity

Antipsychotic drugs toxicity

Antiseizure drugs toxicity

Antitumor drugs selective toxicity

Antitumor drugs toxicity

Beta-blocking drugs toxicity

Bone Marrow Toxicity Testing During Drug Development

Bone marrow toxicity test during drug development

Calcium channel-blocking drugs toxicity

Children drug toxicity

Covalent binding drug toxicity

Delayed drug reactions toxic epidermal necrolysis

Drug and toxicity

Drug concentration minimum toxic

Drug delivery systems toxicity reduction

Drug design toxicity mechanisms

Drug design toxicity problem

Drug development bone marrow toxicity test

Drug development toxicity studies

Drug discovery toxicity

Drug substance relative toxicity

Drug toxicity clinical side effects

Drug toxicity idiosyncratic reactions

Drug toxicity serum gentamicin

Drug toxicity, genetic factors

Drug toxicity, minimizing

Drug-Induced Pancreatic Exocrine Toxicity in Humans

Drug-induced toxicity

Drugs enantioselective toxicity

Drugs environmental toxicity

Drugs for treatment toxicity

Drugs toxic

Drugs toxic

Drugs, toxic, liquid

Drugs, toxic, solid

Extracorporeal Therapy of Patients with Drug Toxicity

Genomics Applications that Facilitate the Understanding of Drug Action and Toxicity

Horses drug toxicity

Human studies drug toxicity

Hypotension antipsychotic drug toxicity

Importance of functional groups in determining drug actions and toxicity

Integrating Novel Imaging Technologies to Investigate Drug-Induced Kidney Toxicity

Intraperitoneal drug administration toxicity

Kidney drug adverse effects/toxicity

Lactation, drug toxicity

Liver drug toxicity

Liver drug toxicity enhancement

Lungs cytotoxic drug toxicity

Neuromuscular blocking drugs toxicity

Nonsteroidal anti-inflammatory drugs toxicity

Ocular drug delivery toxicity

Pharmaceuticals drug toxicity

Preclinical Safety Assessment of Drug Candidate-Induced Pancreatic Toxicity From an Applied Perspective

Pregnancy drug toxicity

Psychiatric drugs toxicity with

Pulmonary toxicity, drug-induced

Role of Covalent Binding in Drug Toxicity

Sedative-hypnotic drugs toxicity

Selective toxicity antifungal drugs

Selective toxicity antiparasite drugs

Selective toxicity antiviral drugs

Significance of stereoisomerism in determining drug action and toxicity

The Enantioselective Toxicities of Drugs and Pharmaceuticals

Therapeutic and Toxic Levels of Drugs

Thrombolytic drugs toxicity

Toxic and beneficial drug effects

Toxic epidermal necrolysis allergic drug reaction

Toxic epidermal necrolysis drug-related

Toxic substances, psychoactive drugs

Toxicity Interactions, drug

Toxicity antineoplastic drugs

Toxicity drug design

Toxicity drug discovery phase

Toxicity drug discovery programs

Toxicity drug-induced psychosis

Toxicity herbal drugs

Toxicity liver, drug-induced

Toxicity malaria drugs

Toxicity of drugs

Trapping studies drug toxicity

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