Toxicity disintegrated polymers

Inert matrices are manufactured with polymers that form an indigestible and insoluble skeleton after compression. These polymers must accomplish different requirements such as ability to form a porous and non-disintegrable net after compression, insolubility in the gastrointestinal fluids, compatibility with the drug and other excipients, and lack of toxicity [2]. Examples of materials that are used as inert matrix-forming polymers are metacrylate copolymers (Eudragit RS), ethyl cellulose, dibasic calcimn phosphate, polyvinylacetate (PVA), etc. 

There should be no accumulation of particulate residues in the soil. Disintegration and bioassimilation of the polymer should not lead to the formation of soluble toxic products in the soil. 

---