Toxicity carbonyl difluoride

The effects of carbonyl difluoride on humans is recorded in case histories but, for obvious reasons, there are few quantitative data in the literature. Consequently, the toxicity of COFj has been investigated by many workers using a variety of vertebrate animals other than man. These investigations are summarised in Table 13.1. From the literature, it is possible... 

Perfluoroisobutene PFIB (CF3)jC=CFj is noted for its high toxicity, and it has been suggested by Danishevskii and Koganov that it is the formation of COF in vivo that produces the toxic effects [4Slaa]. This view is considered doubtful, not least because carbonyl difluoride has been shown to be approximately 130 times less toxic than PFIB [393a]. Further discussion of the likely biological action of PFIB is presented elsewhere [393a,394]. 

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