Total Synthesis of - -Solavetivone

Abstracted with permission from J. Org. Chem., 1992,57, 922 1992 American Chemical Society 

Abstracted with permission from J. Am. Chem. Soc., 1995,117, 9369 1995 American Chemical Society 

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The reaction of trimethylaluminum [65,66] with cyclohexadienone was also catalyzed by the combination of the oxazoline ligand 28 and copper(I) triflate to afford relatively high selectivity (Scheme 15) [67]. The process was successfully applied to the asymmetric total synthesis of (-)-solavetivone [68]. 

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