Total Syntheses of Zearalenone

Hurd and Tsuji promoted the formation of the macrocycle at the ketone using an internal Dieckmann condensation or an intramolecular alkylation of a protected cyanohydrin (368, 369). 

The latest total syntheses, presented by the groups of Fiirstner (362), Barrett (373), and Yadav (374), are aU based on a ring-closing metathesis (RCM) as the key step. In the following sections, several total syntheses of zearalenone (479) will be described. 

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