Tosy lation

The mediation of 83 to 85 followed by iodination and catalytic hydrogenoly- is gives 87, Compound 86 has been synthesised via controlled mediation or tosy-lation at the 3 -position, iodination and reduction. A patent from Megi describes the conversion of the 3 -to l derivative into the 3, 4 epoxy compound and the catalytic reduction to 86. 3 -Epi-4 -deoxyneamine, 88. is prepared using NaBH4 for the reduction The preparation of 3, 4 -epoxyneamine derivatives 100,... 

There are two different ways of making 2-ethoxyoctane from 2-octanol using the Williamson ether synthesis. When pure (—)-2-octanol of specific rotation —8.24° is treated with sodium metal and then ethyl iodide, the product is 2-ethoxyoc-tane with a specific rotation of —15.6°. When pure (—)-2-octanol is treated with tosyl chloride and pyridine and then with sodium ethoxide, the product is also 2-ethoxyoctane. Predict the rotation of the 2-ethoxyoctane made using the tosy-lation/sodium ethoxide procedure, and propose a detailed mechanism to support your predictioa 14-43 Under base-catalyzed conditions, several molecules of propylene oxide can react to give short polymers. Propose a mechanism for the base-catalyzed formation of the following trimer. 

Preparation by a three-step synthesis first, tosy-lation of a-methoxyphloroacetophenone with 0CH2CH=CH2 p-toluenesulfonyl chloride in the presence of... 

---