Toremifene Rifampicin

ANTIARRHYTHMICS - disopyramide, propafenone 2. ANTIBIOTICS-chloramphenicol, doxycycline, metronidazole, rifampicin, telithromycin 3. ANTICANCER AND IMMUNOMODULATING DRUGS - carmustine, cidosporin, corticosteroids, doxorubicin, etoposide, ima-tinib, lomustine, paditaxel, tacrolimus, tamoxifen, toremifene, vinca alkaloids 4. ANTICOAGULANTS - ORAL 5. ANTI-... 

Rifampicin increases the metabolism of toremifene, and might be expected to reduce its efficacy. 

A study in 9 healthy men found that rifampiein 600 mg daily for 5 days redueed the AUC, peak plasma levels, and half-life of a single 120-mg dose of toremifene by 87%, 55%, and 44%, respectively. Similarly, the AUC of A-demethyltoremifene was reduced by 80%. Rifampicin may therefore reduee the effieaey of toremifene. ... 

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