Topsentia genitrix

Recently, bromodeoxytopsentin (76) and isobromodeoxytopsentin (77) have been isolated from the Korean sponge Topsentia genitrix. They exhibit cytotoxicity against the human leukemic cell line K-562 (LC50 0.6 and 2.1 pg/ml, respectively) [69]. 

G., and Ottinger, R. (1987) Topsentins, new toxic bis-indole alkaloids from the marine sponge Topsentia genitrix. Can. J. Ghent. 65,2118-2121. 

The cytotoxic T. and nortopsentins are isolated from the Mediterranean sponge Topsentia genitrix as well as from deep-sea sponges of the genus Spongosorites. The T. are active against P388 leukemia cells and B16 melanoma cells. 

Braekman, J.C., Daloze, D., and Stoller, C. (1987) Synthesis of topsentin-A, a bisindole alkaloid of the marine sponge Topsentia genitrix. Bull. Soc. Chim. Belg., 96,809-812. 

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