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Topotecan Phenytoin

Isoniazid Avasimibe Bosentan Carbam- a2epine" Clotrimazole Cyproterone acetate Hyperforin Lovastatin Mifepristone Nelfinavir Nifedipine Omeprazole Paclitaxel Phenobarbital Phenytoin Rifabutin Rifampin"" Rifapentine Ritonavir Simvastatin Sulfinpyrazole Topotecan Troglitazone Troleandomycin Vitamin E Vitamin K2 Yin zhi wuang... [Pg.239]

TOPOTECAN ANTIEPILEPTICS-PHENYTOIN 1 efficacy of topotecan due to t plasma concentrations of topotecan lactone and its metabolites by 1.5 Due to induction of further metabolism by hepatic CYP3A4 by phenytoin t dose of topotecan to obtain desired therapeutic results... [Pg.340]

A 5-year-old child with medulloblastoma received a course of topotecan, firstly with phenytoin and then without. Phenytoin increased the total topotecan clearance by 47%. This suggests that an increased topotecan dosage may possibly be needed in the presence of phenytoin in other patients. For a similar effect of antiepileptics on related topoisomerase inhibitors, see Trinotecan + Antiepileptics , p.638 and 9-Aminocamptothecin + Antiepileptics , p.610. [Pg.667]

See other pages where Topotecan Phenytoin is mentioned: [Pg.520]    [Pg.610]    [Pg.667]    [Pg.520]    [Pg.610]    [Pg.667]    [Pg.220]    [Pg.496]    [Pg.1838]    [Pg.667]   
See also in sourсe #XX -- [ Pg.667 ]



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