Topoisomerase poisons

Apart from the topoisomerase poisons, other drugs that trap proteins in ternary complexes include Cisplatin, and Et-743. 

Froelich-Ammon, S. J., Osheroff, N. (1995). Topoisomerase poisons Harnessing the dark side of enzyme mechanism. The Journal of Biological Chemistry, 270, 21429-21432. 

Liu LF. DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 1989 58 351-75. 

Cardarelli M, Serino G, Campanella L et al (1997) Antimitotic effects of usnic acid on different biological systems. Cell Mol Life Sci 53 667-672 Cheng B, Cao S, Vasquez V et al (2013) Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor. PLoS One 8(4) e60770 Cohen PA, Towers GHN (1995) Anthraquinones and phenanthroperylenequinones from Nephroma laevigatum. J Nat Prod 58 520-526... 

Camptothecin is imique in its mechanism of action. It binds to the cleavable complex of topoisomerase I and covalently attached DNA and stabihzes it (Hsiang et al., 1985). This non-degradable DNA/topoisomerase I complex arrests the rephcation fork and thus kills cells by inhibition of DNA synthesis (Hsiang et al., 1989). Camptothecin and its derivatives are therefore also termed topoisomerase poisons . 

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