Topography of the Ribosome

Determination of the spatial juxtaposition of the proteins and RNA within the ribosomal subunits is a major goal in ribosome research. Key functional characteristics can be clearly understood only if the ribosome topography is known. As our understanding of the structure of the individual components increases, there is an increasing need to piece together the structure to provide the functional understanding desired. 

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One can anticipate further advances along the same lines as have been exploited in the study of bacterial ribosomes characterisation and amino acid sequencing of the purified proteins, precise determination of their stoichiometry, and investigations into the topography of the ribosomes using methods for the chemical... 

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