Tocainide, development

Convulsions, complete heart block, and asystole developed in a case of fatal self-poisoning with 400 mg of tocainide (40). 

Many reagents can be used in either pre- or post-column mode. Primary amines may be derivatised using OPA in the presence of a thiol (2-mercaptoethanol, A-acetylcysteine, 3-mercaptopropionate, -butylthiol) or sodium sulfite and by other methods developed primarily for amino acid analysis. EC oxidation or, more usually, fluorescence detection following post-column reaction with OPA/2-mercaptoethanol may be used for primary aliphatic amines, although some compounds, such as tocainide, do not react under all conditions. The OPA/2-mercapto-ethanol derivative of histamine can be oxidised at a potential of -1-0.4 V vs Ag/AgCl, whereas histamine itself requires more than +1.2 The derivative... 

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