Tobramycin iontophoresis

Hobden, J.A., et al. 1989. Tobramycin iontophoresis into corneas infected with drug-resistant... 

D. Maurice. Iontophoresis and transcorneal penetration of tobramycin. Invest Ophthalmol Vis Sci 30 1181-1182 (1989)... 

Rootman, D.S., et al. 1988. Iontophoresis of tobramycin for the treatment of experimental Pseudomonas keratitis in the rabbit. Arch Ophthalmol 106 262. 

Transcorneal iontophoresis of antibiotics for the treatment of corneal ulcers offers a potentially effective method of management. Numerous studies have demonstrated successful penetration of antibiotics into the anterior chamber after iontophoretic treatment, compared with topically eyedrop instillation of the drug [42,58,59,66,67], The efficacy of the treatment was investigated in rabbit eyes after intrastromal injection of Pseudomonas. Gentamicin, tobramycin, and ciprofloxacin iontophoresis resulted in significantly fewer bacterial colonies in the cornea compared with frequent eyedrops instillation [68-71],... 

In ophthalmology, both trans-scleral and transcomeal dmg delivery has been studied. Drags investigated include fluorescein, tobramycin, gentamicin, ticarcillin, cefazolin, dexamethasone and ketoconazole. Iontophoresis has been found to be both safe and effective in delivering the required doses locally, at the intended site of action. Excepting for lidocaine, which has been tested in human volunteers, all the other drags have been tested in rabbits. 

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