Tnfluoromethyl ketones

Preparation of Tnfluoromethyl Ketones and Related Fluorinated Ketones Begue, J P, Bonnet-Dalpon, D Tetrahedron 47. 3207-3258 245 ... 

Lastly, a-trimetfayisflyl enolates have been added to trifluoromethyl ketones to effect Peterson olefination of the tnfluoromethyl ketones [IS (equation 13)... 

When ethyl trifluoroacetylacetate is treated with an allylic alkoxide, tran-sesterification is followed by ester enolate Claisen rearrangement m a process that on decarboxylation yields stereospecifically the tnfluoromethyl ketone product [22] (equation 19)... 

Another reaction that has potential is the intramolecular ene reaction, which preferentially results in five-membered rings Because fluonnated ketones have a propensity for undergoing mtermolecular ene reactions [55], this reaction has tremendous synthetic possibilities Only one example of an ene reaction of an unsaturated tnfluoromethyl ketone has been reported, but it indicates the potential of the methodology [59] (equation 59)... 

Dialkylcadmium reagents are often useful alternatives to the more reactive Grignard reagents in the preparation of ketones from acyl halides However, bis(trifluoromethyl)cadmium glyme is decomposed by acyl halides and does not give tnfluoromethyl ketones K 124] Nevertheless, this reaction can be used as a low-temperature source of difluorocarbene [S, 124] (equation 102)... 

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