Titration of Organolithium Compounds

Halagan-Litifium Exchange [ Y = tiatogen) TrsnsmetaHalion V = metallic elerneni) 

Simple, unfunctionalized organolithium compounds are usually prepared by reductive lithiation of alkyl halides with lithium metal at ambient temperature or above [26]. Reductive lithiation is fastest for alkyllithium compounds (the more substituted the better) and slowest for aryllithium compounds. The order of reactivity follows logically from the relative stabilities of the intermediate radicals, whose formation is the rate-determining step of the sequence. 

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