Titanium silicalites amines

Recently, based on such an oxidative system, the synthesis of nitrone (12) an inhibitor of 5a-reductase has been carried out (Scheme 2.7) (50). Oxidation of amines with H2O2 can be catalyzed with peroxotungstophosphate (PCWP) (51), Se02 (52-54), and titanium silicalite molecular sieves TS-1 and TS-2 (55, 56). 

Microporous and mesoporous amorphous titanosilicates have been made by the sol-gel method from tetraethoxysi-lane and tetrapropyltitanate without amines.261 In contrast with titanium silicalite with hydrogen peroxide, which gives about equal amounts of catechol and hydroquinone,... 

Hydroxylamines can also be prepared from secondary amines using TS-1 (titanium silicalite) as a catalyst with H2O2 [172], or using dioxiranes [173]. 

The system can also be used to oxidize amines to oximes with 88% selectivity at 40% conversion.257 The substitution of other metals for titanium in the silicalite gives catalysts that usually do not work as well. In any... 

---