Tissue bioactive glasses

Bioactive glasses are currently used as granulate for bone and dental grafting in small defects, or as powder incorporated into toothpaste. Although silica-based bioactive glasses meant an extraordinary advance in the field of bone tissue regeneration, their application as pieces for medium and large defects is not possible due to their very poor mechanical properties. 

Ordered mesoporous silica have already been studied as carriers for drug delivery [1,2] recently, their use has also been proposed in bone tissue engineering [3,4], in combination with bioactive glass-ceramic scaffolds [5,6]. The kinetics of ibuprofen release in SBF [7] from MCM-41 silica with similar pore diameter has shown puzzling discontinuities [3,6,8] aim of the present work is to assess whether these anomalies may be related to structural changes in the MCM-41 mesoporous spheres under the adopted conditions. 

Development of nano-structured alumina and zirconia ceramics and composites as well as nano-structured calcium phosphate ceramics and porous bioactive glasses, possibly as composites with organic constituents, will provide desired properties for bone substitution and tissue engineering for the next 20 years (Chevalier and Gremillard, 2009). 

M.M. Pereira, J.R. Jones, L.L. Bench, Bioactive Glass and Hybrid Scaffolds Prepared by Sol-Gel Method for Bone Tissue Engineering, Advances in Applied Ceramics Structural, Functional Bioceramics, 104(1), 35-42 (2005). 

PREPARATION AND CHARACTERISATION OF PLGA-COATED 517 POROUS BIOACTIVE GLASS-CERAMIC SCAFFOLDS FOR SUBCHONDRAL BONE TISSUE ENGINEERING... 

Silica, silver, bioactive glass, heparin, and CaSiOs have been incorporated into the electrodeposition process of chitosan and HA to try and improve performance of composite coatings for biomedical implants that interface with bone tissue [116, 119, 134, 139, 149]. While the electrodeposition methods and mechanical and adhesion strength of the coatings are commonly reported in these studies, little biological data has been gathered on the response of cells or tissues to these composite coatings. 

Beier, J. R, Kneser, U., Horch, R. E., Detsch, R., Boccaccini, A. R., and Arkudas, A. (2014). In vitro and in vivo biocompatibility of alginate dialdehyde/gelatin hydrogels with and without nanoscaled bioactive glass for bone tissue engineering applications, 7,1957-1974. 

Peter, M., Binulal, N. S., Nair, S. V., Selvamurugan, N., Tamura, H., Jayakumar, R. (2010). Novel biodegradable chitosan-gelatin/nano-bioactive glass ceramic composite scaffolds for alveolar bone tissue engineering, Chem./-no. 1.1.58. 353-361. 

R.M. Day, A.R. Boccaccini, S. Shurey, J.A. Roether, A. Forbes, L.L. Hench, et al.. Assessment of polyglycolic add mesh and bioactive glass for soft-tissue engineering scaffolds. Biomaterials 25 (2004) 5857-5866. 

M. Marcolongo, P. Ducheyne, J. Garino, E. Schepers, Bioactive glass fiber/polymeric composites bond to bone tissue, J. Biomed. Mater. Res. 39 (1998) 161-170. 

Examples HA bioactive glasses bioctive glass-ceramics Tissue attachment Intertacial bonding Resorbable bioceramics... 

The approach of making porous composites of P(3HB-co-3HV) with sol-gel bioactive glass (SGBG) and calcium phosphate-loaded collagen (CaP-Gelfix) foams have been tried for bone-tissue engineering. It was found to be useful since it showed formation of a HA layer on the surface of P(3HB-co-3HV)/SGBG... 

Fibrous fillers for biomedical PLA-based FRPs include carbon and inorganic fibres [406], PLLA (i.e. self-reinforcement) [407,408], poly(p-dioxane) fibre [409], chitin [410], biodegradable fibre (e.g. bioactive glass, chitosan fibre, polyester amides) [411], hydroxyapatite fibre [412], hydroxyapatite whiskers [413], halloysite (Al2Si205(0H)4) nanotubes [414] and the fibre from different tissue types of Picea sitchensis [415],... 

Q. Fu, M. N. Rahaman, B. S. Bal, L. F. Bonewald, K. Kuroki, and R. F. Brown, Silicate, Borosilicate, and Borate Bioactive Glass Scaffolds with Controllable Degradation Rate for Bone Tissue Engineering Applications. II. In Vitro and In Vivo Biological Evaluation, J. Biomed. Mater. Res. A, 95, 172-9 (2010). 

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