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TIMMIS Pteridine Synthesis

The second major method for the synthesis of pteridines involves the condensation of a 5-nitrosopyrimidin-4-amine with an a-oxomethylene compound. The formation of 7-methyl-6-phenylpteridine-2,4-diamine (1) from 5-nitrosopyrimidine-2,4,6-triamine and phenylacetone is generally known as the Timmis synthesis.120... [Pg.286]

An example of the use of the Timmis synthesis with an a-methylene ketone is the condensation of 5-nitroso-2-phenylpyrimidine-4,6-diamine with phenylacetone to give 7-methyl-2,6-diphenyl-pteridin-4-amine (1). The use of phenylacetaldehyde gives 2,6-diphenylpteridin-4-amine (2), but in less than 20% yield.121... [Pg.286]

Amino-5-nitrosopyrimidines 2 cyclocondense with systems possessing an activated CH2 group (aldehydes, ketones, nitriles, esters, reactive methylene compounds, phenacylpyridinium salts) providing pteridines 3 on base catalysis Timmis synthesis) ... [Pg.426]

Thorpe-Ziegler cyclization 431 Timmis synthesis (pteridine) 489 Traube synthesis (purine) 476... [Pg.632]

See other pages where TIMMIS Pteridine Synthesis is mentioned: [Pg.375]    [Pg.375]    [Pg.896]    [Pg.896]    [Pg.896]    [Pg.896]    [Pg.88]    [Pg.304]    [Pg.754]    [Pg.934]    [Pg.88]    [Pg.304]    [Pg.754]    [Pg.88]    [Pg.304]    [Pg.754]    [Pg.754]   
See also in sourсe #XX -- [ Pg.375 ]

See also in sourсe #XX -- [ Pg.375 ]



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