Time Profiles of the Model

According to definitions (8.3) and (9.6), the relationship between clearance, volume of distribution, and hazard rate is again recalled  

This relationship is now considered as time-dependent because of h(t), the age-dependent hazard rate in the retention-time models, or because of V (t), the time-varying volume of distribution. For all the above models, the time-concentration curve E [C (/)] in each observed compartment is obtained by dividing E Q (/)] by V (t). For the simplest one-compartment model, two different 

In other words, the expectation of the amount behaves always as the survival function S (f) but the expectation of the concentration behaves either as the 

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