Ticarcillin iontophoresis

M. Barza, C. Peckman, and J. Baum. Transscleral iontophoresis of cefazolin, ticarcillin, and gentamicin in the rabbit. Ophthalmology 93 133-139 (1986)... 

A number of antibiotics, including gentamicin, cephazolin, ticarcillin, amikacin, and vancomycin have been successfully delivered into the vitreous of rabbit eyes (Table 26.2). Barza et al. [74] further investigated the efficacy of transscleral iontophoresis of gentamicin for the treatment of Pseudomonas endophthalmitis in rabbits. They found that two sessions of iontophoresis in addition to an intravitreal injection of gentamicin resulted in a significantly lower number of bacterial colonies in the vitreous than by the injection alone. 

In ophthalmology, both trans-scleral and transcomeal dmg delivery has been studied. Drags investigated include fluorescein, tobramycin, gentamicin, ticarcillin, cefazolin, dexamethasone and ketoconazole. Iontophoresis has been found to be both safe and effective in delivering the required doses locally, at the intended site of action. Excepting for lidocaine, which has been tested in human volunteers, all the other drags have been tested in rabbits. 

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