Tibolone Rifampicin

RIFAMPICIN TIBOLONE 1 tibolone levels Induction of metabolism of tibolone Watch for poor response to tibolone consider t dose... 

On theoretical grounds the manufacturer of tibolone says that the effects of tibolone may be reduced by enzyme-inducing antiepileptics and rifampicin. 

The manufacturer says that on a theoretical basis enzyme inducers such as the barbiturates, carbamazepine, phenytoin and rifampicin may accelerate the metabolism of tibolone and thus decrease its efficacy. However, they note that no examples of these interactions have been reported in clinical practice, and pharmacokinetic studies are required to demonstrate this interaction. Nevertheless it would be prudent to monitor concurrent use. 

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See also in sourсe #XX -- [ ]

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