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Thyroid gland independent regulation

The thyroid gland also regulates its uptake of iodide and thyroid hormone synthesis by intrathyroidal mechanisms that are independent of TSH. These mechanisms are primarily related to the level of iodine in the blood. Large doses of iodine inhibit iodide organification (Wolff-Chaikoff block, see Figure 38-1). In certain disease states (eg, Hashimoto s thyroiditis), this can inhibit thyroid hormone synthesis and result in hypothyroidism. Hyperthyroidism can result from the loss of the Wolff-Chaikoff block in susceptible individuals (eg, multinodular goiter). [Pg.857]

Autoregulation of Thyroid Growth and Function by Iodine Independent Regulation of the Thyroid Gland by lodocompounds... [Pg.243]


See other pages where Thyroid gland independent regulation is mentioned: [Pg.206]    [Pg.789]    [Pg.159]    [Pg.421]    [Pg.408]    [Pg.463]    [Pg.455]    [Pg.237]   


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Thyroid gland

Thyroid gland regulation

Thyroid regulation

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