Thymidine phosphorylase inhibitor

Kawauchi T, Matsumoto H, Yano S (2001) Determination of a new thymidine phosphorylase inhibitor, TPI, in dog and rat plasma by reversed-phase ion-pair high-performance liquid chromatography. J Chromatogr Biomed Appl 751(2) 325-330... 

Swain and Lupton s parameters [32] have been used by Coats, Glave and Hansch in their study of substituted uracils as thymidine phosphorylase inhibitors [18]. 

Cole, C., Reigan, R, Gbaj, A., Edwards, P. N., Douglas, K. T., Stratford, I. J., Freeman, S., Jaffar, M. Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives inhibitors of the angiogenic enzyme thymidine phosphorylase. J. Med. ChettL 2003, 46, 207-209. 

McNally, V.A., Gbaj, A., Douglas, K.T., Stratford, I.J., Jaffar, M., freeman, S., and Bryce, R.A. (2003) Identification of a novel class of inhibitor of human and Escherischia coli thymidine phosphorylase by in silico screening. Bioorganic ej Medicinal Chemistry Letters, 13, 3705-3709. 

Emura T, Suzuki N, Fujioka A, Ohshimo H, Fukushima M (2005) Potentiation of the antitumor activity of a, a, a-tiifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo. Int J Oncol 27 449-456... 

Diab et al ° reported a series of fluorophosphonylated pyrimidine nucleosides (58). These analogues act as thymidine phosphorylase multisubstrate inhibitors. 

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