Thrombin activable fibrinolysis inhibitor TAFI

Thrombin activable fibrinolysis inhibitor (TAFI) is a plasma protein that is activated by thrombin in the presence of thrombomodulin to a labile carboxypeptidase-B-like enzyme that inhibits fibrinolysis. When TAFIa is included in a clot undergoing lysis induced by tPA and plasminogen, the time to achieve lysis is prolonged and free lysine and arginine are released (Wang et al., 1998). TAFIa retards the fibrin-enhanced activation of plasminogen by tPA and inhibits the accumulation of plasminogen at the lysis front (Sakharov et al., 1997). 

Boffa MB, Hamill JD, Maret D, et al. Acute phase mediators modulate thrombin-activable fibrinolysis inhibitor (TAFI) gene expression in HepG2 cells. J Biol Chem 2003 278(1 l) 9250-9257. 

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