Three-dimensional structure transferrins

The most detailed description of a complete transferrin molecule is that of human lactoferrin, at 2.8-A resolution (78), and most of the data in the following sections come from this work and from refinement of the same structure at 2.1-A resolution (79). As would be expected from the high level of sequence similarity, the three-dimensional structure of rabbit serum transferrin (68), although at lower resolution (3.3 A), is completely consistent with that of lactoferrin the differences are at the level of individual amino acid changes, together with some differences in lobe and domain orientations. These are discussed below (Section III.B.l). 

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