Three-dimensional database search

DP Mamott, IG Dougall, P Meghani, Y-J Liu, DR Flower. Lead generation using pharmacophore mapping and three-dimensional database searching Application to muscarinic M3 receptor antagonists. J Med Chem 42 3210-3216, 1999. 

Kurogi Y, Miyata K, Okamura T, Hashimoto K, Tsutsumi K, Nasu M, Moriyasu M. Discovery of novel mesangial cell proliferation inhibitors using a three-dimensional database searching method. J Med Chem 2001 44 2304-7. 

SPLICE - a program to assemble partial query solutions from three-dimensional database searches into novel ligands. 

Kurogi, Y. and Guner, O.F. Pharmacophore modeling and three-dimensional database searching for dmg design using catalyst. Curr. 

Kaminski, J.J., Rane, D.F., Snow, M.E., Weber, L, and Rothofsky, M.L Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods./. Med. Chem. 1997, 40, 4103-4112. 

Greenidge, P.A., Carlsson, B., Biadh, L.G., and Gillner, M. Pharmacophores incorporating numerous excluded volumes defined by x-ray crystallographic structure in three-dimensional database searching application to the thyroid hormone receptor./. Med. Chem. 1998, 41, 2503-2512. 

Warr W. A., Willett P. The Principles and Practice of Three-Dimensional Database searching, in Design of Bioactive Molecules, American Chemical Society, Washington D.C., 1998,... 

Nicklaus, M.C., Neamati, N., Hong, H., Mazumder, A., Sunder, S., Chen, J. et al. (1997) HlV-1 integrase pharmacophore discovery of inhibitors through three-dimensional database searching. 

Kaminski JJ, Rane DF, Snow ME, Weber L, Rothofsky ML, Anderson SD, Lin SL. Identification of novel famesyl protein transferase inhibitors using three-dimensional database searching methods. J Med Chem 1997 40 4103 4112. 

Three-dimensional database searching of bioactive compounds and their application 00YGK676. 

Three-dimensional database searching algorithms are available as add-on modules for some popular molecular modeling packages. An add-on module... 

Finn PW, Snarey M. Flexible three-dimensional database searching for the identification of novel lead compounds. In Bioactive Compound Design. Ford. Martyn G. (ed). Oxford. UK Bios Scientific Publishers. 1996 pp. 67-76. 

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