Three-Component Reactions Using Supported Reagents

7 THREE-COMPONENT REACTIONS USING SUPPORTED REAGENTS 

Supported reagents have several advantages in organic chemistry such as the production of resin-bound products, increased stability, and easy purification. Despite these advantages, very few supported reagents have been used in MCRs, in front of the most common approach of using supported catalysts. In this chapter, we will discuss some of the most attractive examples for the use of supported reagents in MCRs. 

the same research group reported a similar [4h-2]/ [3+2] sequential cycloaddition of resin-bound nitroalkenes, ethyl vinyl ether, and styrene under high-pressure conditions [88]. The cycloadducts were obtained in moderate yields (29-51%) as a mixture of diastereomers. 

Keshavarz and Albadi used an azide-supported reagent in a macroporous polymer for developing click chemistry [91]. The reaction involves the nucleophihc addition of the supported azide to a-bromo carbonyl compounds (ketones, amides, or esters) followed by the 1,3-dipolar cycloaddition of the preformed azide to an alkyne catalyzed by a polymer-supported 

Cu(I) complex. This process afforded the desired 1,4-disubstituted 1//-1,2,3-triazoles in good yields and with complete regioselectivity (78-92% yields, 16 examples). 

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