Three-component domino Henry Michael reactions

Scheme 4.34 Multicatalysed three-component domino Henry/Michael reaction.

In another context, Frechet et al. have described a polarity-directed three-component domino Henry-Michael reaction of two aliphatic aldehydes with different polarities and nitromethane catalysed by a combination of chiral diphenylprolinol trimethylsilyl ether and L-proline. In this original process. 

Scheme 2.25 Three-component domino Henry-Michael reaction catalysed by a combination of chiral diphenylprolinol trimethylsilyl ether and L-proline.

Scheme 10.28 Three-component domino Michael/aza-Henry/hemiaminalization reaction followed by TiCl4-mediated allylation/cyanation.

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