Third Generation Copper-Catalyzed Aerobic Oxidation Protocol

Third Generation Copper-Catalyzed Aerobic Oxidation Protocol 

The stringent requirement for 2 equivalents of K2C03 in toluene was puzzling and we initiated some studies in order to understand the role(s) of this heterogeneous base. In particular, we wondered if suitable reaction conditions might be found in which smaller quantities of base could be employed in order to transform our original system into a more ecologically friendly protocol. 

5mol% CuCl.Phen toluene 90°C 5mol% DBAD-H2 2eqs K2C03 02 

6Neral was not detected in this reaction. cGeranial was not detected in this experiment. 

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IV. Third Generation Copper-Catalyzed Aerobic Oxidation Protocol... 

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