Third example polycrystalline particles of paracetamol

Paracetamol agglomerates were prepared by the spontaneous precipitation of paracetamol into a mixture containing hexane, tetrahydrofuran and dichloromethane under stirring. All the crystals obtained were filtered under vacuum. 

The melting point of paracetamol being 169°C and the transition temperature being 156°C, different drying conditions were tested (Table 15.2.3.2)  

After drastic drying at 100°C and progressive drying, a test with complementary drying at 156°C was carried out for 10 minutes. 

All the recovered crystals were packaged in glass flasks before gas phase chromatography and other analysis. 

The implantation of peripherical crystallites is perpendicular to the surface. As it has been clearly demonstrated by Ettabia a nucleus is formed first and then, in a second step, microcrystallites grow on it. 

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